Лаборатория молекулярной нейродегенерации (ЛМН)

Лаборатория занимается нейродегенеративными заболеваниями, такими как: болезнь Альцгеймера (БА), болезнь Паркинсона (БП), боковой амиотрофический склероз (болезнь Шарко), болезнь Хантингтона (БХ) и спиномозжечковые атаксии (СМА)

Подробное описание

Публикации

  1. Jun Wu, Daniel Ryskamp, Xia Liang, Polina Egorova, Olga Zaharova, Gene Hung, and Ilya Bezprozvanny. Enhanced store-operated calcium entry leads to striatal synaptic loss in Huntington's disease mouse model. Journal of Neuroscience. 2016 vol 36, pp 125–141
  2. Fisher, A., Bezprozvanny, I., Wu, L., (...), LaFerla, F.M., Medeiros, R. AF710B, a novel M1/σ1 agonist with therapeutic efficacy in animal models of Alzheimer's disease.Alzheimer's disease Volume 16, Issue 1-2, 1 February 2016, Pages 95-110
  3. Popugaeva, E., Pchitskaya, E., Bezprozvanny, I. Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity? Biochemical and Biophysical Research Communication September 06, 2016
  4. Zhang, H., Sun, S.,  Wu, L.,  Pchitskaya, E.,  Zakharova, Oc,  Tacer, K.F.,  Bezprozvanny, I. Store-operated calcium channel complex in postsynaptic spines: A new therapeutic target for alzheimer’s disease treatment  (Article). Journal of Neuroscience Volume 36, Issue 47, 23 November 2016, Pages 11837-11850
  5. Zhemkov, V.A., Kulminskaya, A.A., Bezprozvanny, I.B., Kim, M.The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin FEBS Open Bio Volume 6, Issue 3, February 01, 2016, Pages 168-178
  6. Polina Egorova, Olga Zaharova Olga Vlasova and Ilya Bezprozvanny In vivo analysis of cerebellar Purkinje cell activity in SCA2 transgenic mouse model. Journal of Neurophysiology Volume 7, Issue 1, 1 March 2016, Pages 78-86
  7. M V Matveev, A I Erofeev2 O A Zakharova, E N Pyatyshev, A N Kazakin, and O L Vlasova. Implantable optical-electrode device for stimulation of spinal motoneurons. Journal of Physics: Conference Series Volume 741, Issue 1, 15 September 2016
  8. Erofeev, A.I., Zakharova, O.A. , Matveev, M.V., Terekhin, S.G., Bezprozvanny, I.B., Vlasova, O.L. Use of optogenetic technology in cell culture models. Journal of Physics: Conference Series Volume 741, Number 1
  9. Jun Wu, Daniel Ryskamp, Xia Liang, Polina Egorova, Olga Zaharova, Gene Hung, and Ilya Bezprozvanny Enhanced store-operated calcium entry leads to striatal synaptic loss in Huntington's disease mouse model. Journal of Neuroscience, vol 36, pp 125–141
  10. N.A. Kraskovskaya, E O. Kukanova, N.S. Lin’kova,E. A. Popugaeva, and V. Kh. Khavinson. Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer’s Disease. Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 101-104, June, 2017.
  11. Popugaeva E.A., Pchitskaya E.I., Bezprozvanny I.B.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease – A therapeutic opportunity? Biochemical and Biophysical Research Communications Volume 483, Issue 4, 19 February 2017, Pages 998-1004.
  12. Pchitskaya E.I., Popugaeva E.A., Bezprozvanny I.B.Calcium signaling and molecular mechanisms underlying neurodegenerative diseases. Cell Calcium 2017, DOI: 10.1016/j.ceca.2017.06.008
  13. Vladimir Khavinson, Natalya Linkova, Ekaterina Kukanova, Anastasiya Bolshakova, Anastasiya Gainullina, Soomon Tendler, Ekaterina Morozova, Svetlana Tarnovskaya, Deby Susanti Pada Vinski, Vladimir Bakulev and Nina Kasyanenko. Neuroprotective Effect of EDR Peptide in Mouse Model of Huntington's Disease. Journal of Neurology and Neuroscience, Vol.8 No.1:166, DOI: 10.21767/2171-6625.1000166, 2017.
  14. V. Bol’shakova, N.A. Kraskovskaya , A.N.Gainullina, E.O. Kukanova, O.L.Vlasova, I.B.Bezprozvanny. Neuroprotective Effect of σ1-Receptors on the Cell Model of Huntington’s Disease. Bulletin of Experimental Biology and Medicine. December 2017, Volume 164, Issue 2, pp 252–258
  15. A I Erofeev , M V Matveev , O A Zakharova , S G Terekhin , V A Kilimnik , I B Bezprozvanny and O L Vlasova. Optogenetic light pulses generator. Journal of Physics: Conference Series, Volume 917, Nanobiotechnology, Biophysics and Biophotonics, Published online: 23 November 2017
  16. Bezprozvanny, I., Sorgato, M.C., Carafoli, E. Misery loves company – shared features of neurodegenerative disorders. Biochemical and Biophysical Research Communications. Volume 483, Issue 4, 19 February 2017, Pages 979-980
  17. Korban, S.A., Bobrov, K.S.,  Maynskova, M.A.,  Naryzhny, S.N.,  Vlasova, O.L.,  Eneyskaya, E.V.,  Kulminskaya, A.A. Heterologous expression in Pichia pastoris and biochemical characterization of the unmodified sulfatase from Fusarium proliferatum LE1. Protein Engineering, Design and Selection. Volume 30, Issue 7, 1 July 2017, Pages 477-488
  18. Zhurishkina, E.V., Stepanov, S.I., Shvetsova, S.V., Kulminskaya, A.A., Lapina, I.M. A comparison of the effect of fucoidan from alga Fucus vesiculosus and its fractions obtained by anion-exchange chromatography on HeLa G-63, Hep G2, and Chang liver cells. Cell and Tissue Biology. Volume 11, Issue 3, 1 May 2017, Pages 242-249
Безпрозванный Илья Борисович
Занимаемые должности
именной профессор отдела Физиологии Юго-Западного Медицинского Центра Университета Штата Техас Даллас США
Ученые степени
доктор биологических наук
Ученое звание
доцент
Академическое звание
член - корреспондент Российской Академии Наук
Ерофеев Александр Игоревич
Ученые степени
кандидат физико-математических наук
Попугаева Елена Александровна
Занимаемые должности
Ученые степени
доктор биологических наук